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KMID : 0603519990040020079
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 2 p.79 ~ p.85
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In Vitro Anticarcinogenic Effect of Kimchi Fractions
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Cho Eun-Ju
Lee Sook-Hee
Park Kun-Young
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Abstract
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Anticarcinogenic effect induced by 3-methylcholanthracene (MCA), and 7,12-dimethyl-benz (a) anthracene (DMBA) of chinese cabbage kimchi fractions was studied by using C3H/10T1/2 cells. The chinese cabbage kimchi (4 day fermented at 1 5℃) was fractionated into 7 groups, methanol extract, hexane fraction (fr.), methanol soluble fr., dichloromethane fr., ethylacetate fr., butanol fr. and aqueous fr. Kimchi fractions decreased significantly the cytotoxicity mediated by the carcinogens, MCA and DMBA in C3H/10T1/2 cells, showing that kimchi plays a role to protect cells against toxic effect of the carcinogens in vitro. In particular, the dichloromethane fr. exhibited strong inhibitory activity of the cytotoxicity induced by the carcinogens compared to other fractionated samples. On the transformation of the cells induced by MCA and DMBA, the dichloromethane fr. reduced the formation of type Ⅱ and Ⅲ foci, especially type Ⅲ foci. When the dichloromethane fr. (0.01 ㎎/㎖) was treated, the numbers of type Ⅱ+Ⅲ foci mediated by MCA and DMBA were decreased to 11 and 8 compared to 22 and 26 of the controls, respectively. These results indicate that the dichloromethane fr. of kimchi may contain the major compound(s) that suppress the carcinogenesis by MCA and DMBA in the eukaryotic cells.
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KEYWORD
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Kimchi, Anticarcinogenic effect, MCA, DMBA, C3H/10T1/2 cells
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